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荧光纳米颗粒,比如量子点、染料包被的纳米颗粒、稀土纳米颗粒等,在过去的几十年里得到广泛的研究和应用,这主要因为它们具有特殊的化学与光电子性质,比如较强的发光强度、较高的稳定性、较大的Stocks位移以及灵活的加工制作性能等.将荧光纳米颗粒引入分析化学将为荧光分析检测提供新的平台.我们立足国内的研究,重点介绍荧光纳米颗粒的化学与生物传感应用,包括对pH值、离子、有机化合物、生物小分子、核酸、蛋白、病毒、细菌等的分析检测.另外,也介绍了荧光纳米颗粒的体外、体内的成像应用.对纳米颗粒应用于分析检测的优势以及信号传导模式也进行了讨论.
Fluorescent nanoparticles, such as quantum dots, dye-coated nanoparticles, rare earth nanoparticles, etc., have been widely studied and applied for decades because of their special chemical and optoelectronic properties, such as strong Luminescence intensity, high stability, large Stocks displacement and flexible processing and manufacturing performance etc. The introduction of fluorescent nanoparticles into analytical chemistry will provide a new platform for fluorescence analysis and detection.We focus on domestic research, focusing on fluorescent nanoparticles Chemical and biosensing applications, including analytical assays for pH, ions, organic compounds, biological small molecules, nucleic acids, proteins, viruses, bacteria, etc. In addition, in vitro and in vivo imaging applications of fluorescent nanoparticles are also described. The advantages of using nanoparticles to analyze assays and signal transduction patterns are also discussed.