目的 :探讨Graves病 (GD)患者血清免疫球蛋白的变化及可能影响的因素。方法 :对 40例初发的GD患者血清免疫球蛋白 (IgG ,IgA及IgM)进行检测 ,并与正常对照组相比较。结果 :GD患者的IgG ,IgA分别为 (15 2 3± 2 5 0 )g/L和 (2 6 0± 0 85 )g/L ,分别高于对照组的 (13 38± 2 2 1)g/L和 (2 12± 0 75 )g/L ,P <0 0 5 ;而IgM在二组间差异无显著意义。不同性别及家族史的患者免疫球蛋白间差异无显著意义。IgG与IgA有显著正相关 (r=0 76 3,P <0 0 5 )。结论 :Graves病患者血清中免疫球蛋白的变化可能与发病机制有关 Objective: To investigate the changes of serum immunoglobulin in patients with Graves disease (GD) and the possible influencing factors. Methods: Serum immunoglobulins (IgG, IgA and IgM) were detected in 40 newly diagnosed GD patients and compared with the normal control group. Results: The levels of IgG and IgA in patients with GD were (15 2 3 ± 2 50) g ​​/ L and (26 0 ± 0 85) g / L, respectively, higher than those in control group (13 38 ± 2 2 1) g / L and (2 12 ± 0 75) g / L, P <0 05, respectively. There was no significant difference in IgM between the two groups. There was no significant difference in immunoglobulin between patients with different genders and family history. There was a significant positive correlation between IgG and IgA (r = 0 763, P <0 05). Conclusion: The changes of serum immunoglobulin in Graves’ disease may be related to the pathogenesis