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目的:评价膜式液基薄层细胞学技术(TCT)、高危型人乳头状瘤病毒(HR-HPV)检测和阴道镜下宫颈活检对子宫颈病变的临床诊断价值。方法:320例TCT检查异常的患者中,160例应用PCR荧光技术检测HR-HPV,186例进行阴道镜检查并取宫颈组织活检,136例同时行HR-HPV检测与阴道镜检查并取宫颈组织活检。以病理学作为诊断标准,比较3种方法对宫颈病变的诊断价值。结果:HR-HPV检测的阳性率56.9%;宫颈活检者病理学诊断为上皮内病变者135例,占72.6%;同时行HR-HPV检测与电子阴道镜宫颈活检的患者中,84例HR-HPV检测阳性者中CIN占32.1%,HR-HPV检测阴性者中CIN占13.5%(P<0.05)。结论:TCT、HR-HPV检测与阴道镜下宫颈活检均是子宫颈病变早期诊断的检测方法,三者各有优缺点,不能相互替代,三者结合能提高宫颈病变的检出率。
Objective: To evaluate the value of TCT, HR-HPV and colposcopic biopsy in the diagnosis of cervical lesions. Methods: Of the 320 cases with abnormal TCT, 160 cases were detected by PCR fluorescence technique, 186 cases were examined by colposcopy and biopsy of cervical tissue, 136 cases were examined by HR-HPV and colposcopy and cervical tissue Biopsy. Using pathology as diagnostic criteria, the diagnostic value of three methods for cervical lesions was compared. Results: The positive rate of HR-HPV test was 56.9%. Among the pathologically diagnosed cervical intraepithelial neoplasms, 135 cases were diagnosed as intraepithelial lesions, accounting for 72.6%. Among HR-HPV testing and electronic vaginal biopsy, 84 cases of HR- CIN accounted for 32.1% of HPV-positive patients and 13.5% of HR-HPV-negative patients (P <0.05). Conclusion: TCT, HR-HPV test and colposcopic cervical biopsy are the detection methods of early diagnosis of cervical lesions. Each has its own advantages and disadvantages, can not replace each other, the combination of the three can improve the detection rate of cervical lesions.