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目的 探讨克山病与乙型肝炎病毒 (HBV)感染的关系。方法 采用病例对照研究方法 ,以确诊的 12 7例克山病人为病例组 ,平衡年龄、性别和民族等影响因素 ,随机抽 12 2例病区健康人作为内对照组 ,非病区健康人 47例为外对照组 ;用酶联免疫 (ELISA)法筛检 3组人群中HBV感染者。数据资料管理和 χ2 检验在SPSS10 .0软件包上进行。结果 HBV感染率在病区与非病区人群间有显著性差异 (P <0 .0 1,OR =3 .94) ,而病区健康人群与克山病人群间无显著性差异 (P >0 .0 5 )。提示克山病与HBV感染有关联 ,且呈剂量 -反应关系 (r =0 .93 5 ,P <0 .0 1)。结论 在克山病区 ,HBV感染可能是人易患克山病的重要危险因素 ,应当重视人群中HBV感染的监测和预防 ,改善当地居民的生活水平和卫生条件
Objective To investigate the relationship between Keshan disease and hepatitis B virus (HBV) infection. Methods A case-control study was conducted. A total of 12 7 cases of Keshan patients were selected as the case group. Balance age, gender and ethnicity were used as the control group. 122 healthy people were randomly selected as the internal control group and 47 Cases of external control group; enzyme-linked immunosorbent assay (ELISA) screening of three groups of people infected with HBV. Data management and χ2 testing were performed on the SPSS10.0 software package. Results The HBV infection rate was significantly different between the ward and the non-ward (P <0.01, OR = 3.94), while there was no significant difference between the healthy ward and the Keshan disease (P> 0 .0 5). This suggests that Keshan disease is associated with HBV infection and has a dose-response relationship (r = 0.93 5, P <0.01). Conclusion HBV infection may be an important risk factor for Keshan disease in Keshan ward. Therefore, we should pay attention to the monitoring and prevention of HBV infection in the population and improve the living standard and hygiene conditions of local residents