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目的:探讨新生儿脐血和生后血清高迁移率族蛋白-1(HMGB1)变化对新生儿窒息的诊断及窒息后脑损伤的判断价值。方法:对窒息新生儿脐血及生后3～7天血清HMGB1变化进行分析。结果:①窒息新生儿脐血HMGB1水平高于正常对照组;②窒息新生儿后3～7天血清HMGB1水平高于正常对照组;③重度窒息新生儿脐血及生后3～7天血清HMGB1水平明显高于轻度窒息新生儿,脐血及生后3～7天血清HMGB1窒息组间比较差异无统计学意义(P>0.05);④发生脑水肿及颅内出血的患儿生后3～7天血清HMGB1含量显著增高。结论:HMGB1与新生儿窒息密切相关,有助于新生儿窒息的诊断及窒息后脑损伤的判断。
Objective: To investigate the diagnostic value of high mobility group box-1 (HMGB1) in umbilical cord blood and neonatal asphyxia after birth and the value of post-asphyxial brain injury. Methods: Serum levels of HMGB1 in neonates with asphyxia and cord blood in 3 ~ 7 days after birth were analyzed. Results ① The levels of HMGB1 in neonatal asphyxia neonates were higher than those in normal controls; ② The levels of serum HMGB1 in neonates with asphyxia 3 ~ 7 days were higher than those in normal controls; ③ Serum levels of HMGB1 in neonates with severe asphyxia and in neonates 3-7 days after birth (P> 0.05); ④The incidence of cerebral edema and intracranial hemorrhage in children after birth 3 ~ 6 months after birth was significantly higher than that of mild asphyxia neonates, umbilical cord blood and HMGB1 asphyxia group after 3 ~ Seven days serum HMGB1 levels were significantly higher. Conclusion: HMGB1 is closely related to neonatal asphyxia, which is helpful to the diagnosis of neonatal asphyxia and judgments of asphyxia brain injury.