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本文采用HPLC法,研究了8名正常人与7名心律失常患者在口服单剂量300mg心律平后的药代动力学。4名空腹服药者与饱腹服药者的药代动力学参数比较结果,除“Tm”有极显著差异外(p<0.01),其它均无显著差异。肝肾功能正常病人的药代动力学参数与正常人相似,而2例肝或肾功能损害者,心律平在体内消除较为缓慢。正常人与肝肾功能正常病人的t(1/2)分别为2.29±0.49(n=8)和2.28±0.31h(n=5),而肝或肾功能损害者的t(1/2)为4.33±0.33h(n=2)。
In this paper, the HPLC method was used to study the pharmacokinetics of eight normal subjects and seven patients with arrhythmia after a single oral dose of 300 mg. The pharmacokinetic parameters of four fasting and full-service physicians did not show any significant difference except for “Tm” (p <0.01). Pharmacokinetic parameters of normal liver and kidney function in patients with normal and similar, and 2 cases of liver or renal dysfunction, rhythm in the body to eliminate more slowly. The t (1/2) of normal and liver-kidney function patients were 2.29 ± 0.49 (n = 8) and 2.28 ± 0.31h (n = 5) 4.33 ± 0.33h (n = 2).