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本院附属医院内科经过反复进行中草药物筛选发现用大剂量川芎、毕拨两味中药治疗三叉神经痛疗效显著,并进一步用这两味中药制成注射液,定名为颅痛宁。为了阐明其镇痛的功效而进行了一定的药理研究。我院所制的颅痛宁其药物是在药物采购站购买的,经鉴定为川芎(Ligusticum Wallichii Franch)的根基和毕拨(Piper Longum L)的未成熟果实。毕拨成分为胡椒碱(Piperine),四氢胡椒酸,棕榈酸,呱啶,挥发油等其功效主治为温中散寒,行气止痛。治心腹冷痛,寒疝疼痛,头痛、齿痛、呃逆呕吐等(1、2)。川芎含四甲基派嗪、佩络里因
In the department of internal medicine of hospitals of this hospital, it was found that the treatment of trigeminal neuralgia with large doses of Chuanxiong and Bizhu traditional Chinese medicine has a remarkable curative effect through repeated screening of Chinese herbal medicine, and the injection of these two Chinese medicines is further used as the skullcap injection. In order to elucidate the efficacy of its analgesia, some pharmacological studies were performed. The drug Takutonging made in our hospital was purchased at the drug purchasing station and was identified as the root of Ligusticum Wallichii Franch and the immature fruit of Piper Longum L. The ingredients for Piperine, tetrahydropalmitic acid, palmitic acid, acridine, volatile oil, etc. are used to treat cold, cold, and relieve pain. Treatment of confidants, cold pain, cold pain, headache, toothache, hiccups and vomiting (1, 2). Chuanxiong Containing Tetramethyl Pyrazine and Pellucinine