目的了解珠海市户籍居民恶性肿瘤死亡特征,为制定恶性肿瘤的防治对策提供依据。方法收集珠海市户籍居民2006―2013年的死因登记资料,分析珠海市恶性肿瘤死亡率、构成比特征及其变化趋势。结果 2006―2013年珠海市共报告户籍居民恶性肿瘤死亡7 909例,年均粗死亡率为98.04/10万,标化死亡率为91.54/10万。死亡率居前5位的恶性肿瘤分别为肺癌、肝癌、结直肠癌、鼻咽癌、胃癌,占全部恶性肿瘤死亡构成的67.02%。7 909例恶性肿瘤死亡病例中,男性5 080例,女性2 829例,男女性别比为1.80∶1;男性恶性肿瘤标化死亡率为111.86/10万,女性恶性肿瘤标化死亡率为68.08/10万,男性恶性肿瘤标化死亡率是女性的1.64倍,差异有统计学意义(P<0.05)。在40岁以前恶性肿瘤死亡率在50.62/10万以下,45岁迅速上升到85.75/10万,并在75岁左右达到高峰903.22/10万。结论恶性肿瘤是导致珠海市户籍居民死亡的首位原因,其中肺癌又位于恶性肿瘤死亡的首位,男性恶性肿瘤死亡率高于女性,应根据不同人群、不同肿瘤的特点,采取综合性的干预措施,预防和减少恶性肿瘤的发生。 Objective To understand the characteristics of death of malignant tumor of hukou residents in Zhuhai and to provide evidence for the prevention and treatment of malignant tumor. Methods The data of the cause of death of hukou residents in Zhuhai from 2006 to 2013 were collected to analyze the malignant tumor mortality rate, constituent ratio characteristics and their changing trend in Zhuhai. Results From 2006 to 2013, Zhuhai City reported a total of 7 909 deaths from familial residents with malignant tumors, with an annual average crude death rate of 98.04 / 100,000 and a standardized mortality rate of 91.54 / 100,000. The top five malignant tumors were lung cancer, liver cancer, colorectal cancer, nasopharyngeal cancer and gastric cancer, accounting for 67.02% of all malignant tumors. 7909 cases of malignant tumor deaths, 5,080 males and 2,829 females, male to female ratio was 1.80: 1; male standardization of malignant tumor mortality was 111.86 / 100 000, the female malignant tumor standardized mortality was 68.08 / The mortality rate of males was 1.64 times that of females, the difference was statistically significant (P <0.05). The death rate of malignant tumors before the age of 40 was below 50.62 / 100,000, the rate of 45-year-old rose rapidly to 85.75 / 100,000 and reached the peak of 903.22 / 100,000 at 75 years of age. Conclusions Malignant tumors are the first cause leading to the death of domiciled residents in Zhuhai City. Among them, lung cancer ranks the first place in the death of malignant tumors. The mortality rate of malignant tumors in male is higher than that of female. Comprehensive interventions should be taken according to the characteristics of different populations and different tumors. Prevent and reduce the occurrence of malignant tumors.