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目的:观察天麻钩藤饮对自发高血压大鼠血压、易激惹度及Bax表达的影响。方法:将40只SHR大鼠随机分为4组,空白对照组每天给予0.9%的氯化钠溶液;模型对照组第1周每天给予附子溶液,第2周开始每天给予0.9%氯化钠溶液;西药组第1周每天给予附子水提液,第2周开始每天给予雷米普利1mg/(kg·d);中药组第1周每天给予附子水提液,第2周开始每天给予天麻钩藤饮水提液。观察高血压大鼠血压、易激惹度及bax表达的改变。结果:4周后模型对照组SHR大鼠血压、易激惹度及bax表达较空白对照组升高;西药组及中药组SHR大鼠血压、激惹度及bax表达降低(P<0.05),且两组之间无明显统计学差异(P>0.05)。结论:天麻钩藤饮对于肝阳上亢型高血压治疗作用与雷米普利作用相仿。
Objective: To observe the effect of Tianma Gouteng Yin on blood pressure, irritability and Bax expression in spontaneously hypertensive rats. Methods: 40 SHR rats were randomly divided into 4 groups. The blank control group was given 0.9% sodium chloride solution every day. The model control group was given Fuzi solution every day in the first week, 0.9% sodium chloride solution . Western medicine group was given Fufang water extract every day in the first week and ramipril 1 mg / (kg · d) every day from the second week. The Chinese herb group was given Fuzi water extract every day in the first week, Uncaria drinking water extract. The changes of blood pressure, irritability and bax expression in hypertensive rats were observed. Results: After 4 weeks, the blood pressure, the degree of irritability and the expression of bax in SHR rats in model control group were higher than those in blank control group. The blood pressure, irritability and bax expression were decreased in SHR rats in western medicine group and traditional Chinese medicine group (P <0.05) There was no significant difference between the two groups (P> 0.05). Conclusion: The therapeutic effect of Tianma Gouteng Yin on hyperactivity of liver-yang hyperactivity is similar to that of ramipril.