难治性肾病综合征(难治性NS)是指激素治疗无效、或激素依赖、或反复发作,因不能耐受激素的副作用而难以继续用药的原发性肾病综合征,约占原发性肾病综合征的30～50%,是目前临床慢性肾病中治疗最为棘手、预后较差的一种[1]。自2000年来,我们采用中西医结合方法治疗本病,取得了较 Refractory nephrotic syndrome (refractory NS) refers to the hormone therapy is invalid, or hormone dependence, or recurrent, because they can not tolerate the side effects of hormones and difficult to continue treatment of primary nephrotic syndrome, accounting for primary Nephrotic syndrome, 30 to 50%, is currently the most chronic clinical treatment of chronic kidney disease, a poor prognosis [1]. Since 2000, we have adopted the combination of traditional Chinese and western medicine to treat this disease and have achieved more