论文部分内容阅读
目的探讨胃肠道间质瘤的临床特点、诊断及治疗。方法对27例胃肠道间质瘤的临床资料进行回顾分析。结果肿瘤发生部位:胃间质瘤20例(74.1%),小肠间质瘤5例(18.5%),结直肠间质瘤2例(7.4%)。主要症状为腹痛、腹胀,消化道出血,腹部包块,贫血及肠梗阻。免疫组化CD117阳性23例,CD34阳性21例。全部病例均行手术治疗,无手术死亡。结论胃肠道间质瘤消化道症状无特异性,术前确诊率低,容易造成误诊;CD117和CD34阳性可作为胃肠道间质瘤诊断标志;根治性手术仍是目前G IST的首选治疗,靶向治疗将成为G IST治疗的重要手段。
Objective To investigate the clinical features, diagnosis and treatment of gastrointestinal stromal tumors. Methods The clinical data of 27 cases of gastrointestinal stromal tumors were retrospectively analyzed. Results Tumor site: 20 cases of gastric stromal tumor (74.1%), 5 cases of small intestinal stromal tumor (18.5%), 2 cases of colorectal stromal tumors (7.4%). The main symptoms of abdominal pain, abdominal distension, gastrointestinal bleeding, abdominal mass, anemia and intestinal obstruction. Immunohistochemical CD117 positive in 23 cases, CD34 positive in 21 cases. All patients underwent surgical treatment, no surgical death. Conclusion Gastrointestinal stromal tumors have no specific gastrointestinal symptoms and preoperative diagnosis is low, which may lead to misdiagnosis. CD117 and CD34 positive can be used as diagnostic markers of gastrointestinal stromal tumors. Radical surgery is still the first choice of treatment for G IST , Targeted therapy will become an important means of G IST treatment.