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目的 探讨抗核抗体（ANA）、抗核抗体谱（ANAs）及抗双链DNA抗体（抗dsDNA抗体）的联合检测对系统性红斑狼疮（SLE）的诊断价值。方法 选择2012年1月至2014年1月间泉州市某市级医院收治的SLE患者150例作为SLE组，同期收治的其他风湿性疾病患者30例作为疾病对照组，门诊体检健康者30例作为正常对照组。应用间接免疫荧光法检测血清 ANA ，应用免疫印迹法检测血清ANAs和抗dsDNA抗体水平。结果 SLE组ANA、抗dsDNA抗体、抗AHA、抗nRNP、抗AnuA、抗Sm阳性率显著高于疾病对照组和健康对照组（ P ＜0．01）。S L E患者中仅5．33％的患者出现单项抗体阳性，其余94．67％的患者一次性检测出2项或以上抗体阳性。SLE患者治疗后ANA、抗dsDNA抗体、抗AHA、抗Sm和抗SS‐A阳性率均不同程度下降，其中ANA、抗dsDNA抗体、抗AHA好转率分别为23．33％、83．33％和63．33％。结论 SLE患者ANA、ANAs和抗ds‐DNA抗体阳性率较高，联合检测和动态观察 ANA、ANAs和抗 ds‐DNA抗体对SLE诊断和治疗具有一定意义。“,”Objective] To explore the value of antinuclear antibody(ANA) ,antinuclear antibody profile(ANAs) and anti‐double stranded DNA antibody (anti dsDNA antibody ) in the diagnosis of systemic lupus erythematosus (SLE) .[Methods] Totally 150 patients with SLE in a municipal hospital of Quanzhou city from Jan .2012 to Jan . 2014 were selected as SLE group ,and other 30 patients with rheumatic diseases were selected as disease control group ,and 30 health examination persons were selected as normal control group .Serum ANA was detected by indi‐rect immunofluorescence method .Serum ANAs and anti dsDNA antibody were measured by western blotting .[Re‐sults] The positive rates of serum ANA ,anti dsDNA antibody ,anti‐AHA ,anti‐nRNP ,anti‐AnuA and anti‐Sm in SLE group were significantly higher than those in disease control group and healthy control group( P <0 .01) .In SLE group ,only 5 .33% of patients had single positive antibody ,and the remaining 94 .67% of patients had two or more positive antibodies .After treatment ,the positive rates of ANA ,anti dsDNA antibody ,anti‐AHA ,anti‐Sm and anti‐SS‐A in SLE patients were decreased in different degree .The improvement rate of ANA ,anti‐dsDNA antibody and anti‐AHA were 23 .33% ,83 .33% and 63 .33% ,respectively .[Conclusion] The positive rates of ANA ,ANAs and anti ds‐DNA antibody in SLE patients is higher .The joint detection and dynamic observation of ANA ,ANAs and anti‐ds‐DNA antibody is of significance in the diagnosis and treatment of SLE .