目的:系统评价人工牛黄甲硝唑胶囊、阿莫西林联合西帕依固龈液治疗单纯性牙周炎的临床效果。方法:收集2012年3月~2015年1月来我院就诊的单纯性牙周炎患者172例,随机分为试验组和对照组,每组86例。对照组仅给予人工牛黄甲硝唑胶囊和阿莫西林治疗,试验组额外给予西帕依固龈液治疗,观察两组患者治疗后疗效差异。结果:试验组治疗后出血指数、牙周袋深度、前牙覆盖程度、HP阳性率及并发症发生率均低于对照组,而治疗有效率高于对照组,分别经t检验或卡方检验,差异均具有统计学意义(P<0.05)。结论:人工牛黄甲硝唑胶囊、阿莫西林联合西帕依固龈液治疗单纯性牙周炎具有可靠的临床疗效和较低的并发症发生率。 OBJECTIVE: To systematically evaluate the clinical efficacy of artificial bezoar metronidazole capsules and amoxicillin combined with Xipayilian gum in the treatment of simple periodontitis. Methods: A total of 172 simple periodontitis patients who came to our hospital from March 2012 to January 2015 were randomly divided into experimental group and control group, with 86 cases in each group. The control group was given only artificial bezoar metronidazole capsules and amoxicillin treatment, the experimental group were given additional treatment of Xipayi gingival fluid, the difference between the two groups after treatment was observed. Results: After treatment, bleeding index, periodontal pocket depth, anterior tooth coverage, positive rate of HP and complication rate of the experimental group were lower than those of the control group, and the treatment effective rate was higher than that of the control group. The t test or the chi square test , The differences were statistically significant (P <0.05). Conclusion: Artificial bezoar metronidazole capsules, amoxicillin combined with Xipayi gingival fluid treatment of simple periodontitis has a reliable clinical efficacy and a lower incidence of complications.