Sjogren综合征是一种以外分泌腺为靶器官的自身免疫性疾病.临床上同时伴有慢性甲状腺炎、类风湿性关节炎及肌病、周围神经病变者,则不多见.笔者仅结合所遇一例,报告如下:典型病例:患者女,43岁,农民.住院号:349744.因多汗、心慌三年,四肢关节痛伴眼口发干、声嘶二年,加重一月,于1990年12月5日入院.三年前偶尔受凉后,始感多汗、心慌,未在意.近二年来左膝关节肿痛,逐渐发展至四肢关节,静息时疼痛加重.被人发现脖子发粗,当地医院曾诊为“甲状腺炎、类风湿性关节炎”,经口服甲 Sjogren’s syndrome is an exocrine gland as the target organ of autoimmune diseases .Clinical clinical accompanied by chronic thyroiditis, rheumatoid arthritis and myopathy, peripheral neuropathy are rare .I only with the Case of a case, the report is as follows: Typical cases: Female patient, 43 years old, farmer. Hospital number: 349744. Due to hyperhidrosis, palpitation for three years, joint pain with limbs dry mouth, hoarseness two years, increased in January, in 1990 December 5, admitted to hospital three years ago occasionally cold, began to feel sweating, palpitation, did not care about the past two years, left knee joint swelling and pain, and gradually developed to the limbs and joints, resting pain increased was found in the neck Coarse, the local hospital has been diagnosed as “thyroiditis, rheumatoid arthritis”, oral administration of a