【摘 要】
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The synthesis and spectroscopic characterization of ruthenium complexes (R-1 to R-8) of the type [Ru(A)2(B)],(where A =1,10-phenanthroline/2,2'-bipyridine and B
【机 构】
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Department of Pharmaceutical Chemistry & Toxicology,Rega Institute for Medical Research
论文部分内容阅读
The synthesis and spectroscopic characterization of ruthenium complexes (R-1 to R-8) of the type [Ru(A)2(B)],(where A =1,10-phenanthroline/2,2'-bipyridine and B =3,4,5-tri-OCH3-DPC,4-CH3-DPC,4-N-(CH3)2-DPC,4-NO2-DPC are described.These ligands form bidentate octahedral ruthenium complexes.The title complexes were subjected to in vitro cytotoxic activity measurements against the human cancer T-lymphocyte cell lines MTT assay.In vitro evaluation of these ruthenium complexes revealed cytotoxic activity from 0.24 to 1.4 μg/mL against CEM,0.44 to 1.9 μg/mL against Molt4/C8,0.28 to 1.5 μg/mL against L1210,0.24 to 0.98 μg/mL against HL60,and 0.25 to 1.2 μg/mL against BEL7402,depending the nature of the compound.
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