我们自1981年3月至1985年6月用同位素~(14)C标记的5一Fu示踪,对40只白兔作了两种给药途径(周围静脉、直肠腔内)的研究。直肠腔内采用两种剂型(栓患和乳剂)。给药后进行了直肠壁、肠系膜淋巴结、肝、肺和骨髓内5—Fu浓度的测定,并对4例低位直肠癌患者,在手术台上经肛门一次给予同位素~(14)C标记的5—Fu检剂后, From March 1981 to June 1985, we used isotope ~ (14) C labeled 5-Fu tracer to study 40 rabbits for two routes of administration (peripheral vein, rectal cavity). Two dosage forms (thrombus and emulsion) are used intraluminally. After administration, 5-FU concentrations in the rectal wall, mesenteric lymph nodes, liver, lung, and bone marrow were measured. Four patients with low rectal cancer were given an isotope ~(14)C-labeled 5 on the operating table via the anus. After Fu detection agent