论文部分内容阅读
目的对甘草酸二铵应用于急性药物性肝损伤临床治疗中的效果进行分析。方法选取120例2014年9月-2016年10月期间在我院接受治疗的急性药物性肝损伤患者,1∶1随机分为参照组(接受门冬氨酸钾镁治疗)和实验组(接受甘草酸二铵治疗)各60例,对两种不同药物的治疗效果进行对照研究。结果就治疗显效率和治疗总有效率而言,实验组患者均明显高于参照组[68.33%、91.67%vs.36.67%、71.67%];就血清丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、血清碱性磷酸酶、血清总胆红素等指标复查时间而言,实验组患者均明显短于参照组(P<0.05),组间差异具有统计学意义。结论甘草酸二铵应用于急性药物性肝损伤临床治疗中的效果十分理想,在控制病情、提高治疗效果、缩短病程、改善肝功能以及提高生命质量等方面具有极其显著的优势,值得大力推广。
Objective To analyze the effect of diammonium glycyrrhizinate used in the clinical treatment of acute drug-induced liver injury. Methods A total of 120 patients with acute drug-induced liver injury who were treated in our hospital from September 2014 to October 2016 were randomly divided into control group (receive potassium-magnesium aspartate) and experimental group (receive Glycyrrhizic acid diammonium treatment) 60 cases each, the treatment effect of two different drugs for controlled study. Results In terms of the effective rate of treatment and the total effective rate of treatment, the patients in the experimental group were significantly higher than the reference group [68.33%, 91.67% vs.36.67%, 71.67%]; serum alanine aminotransferase, aspartate Aminotransferase, serum alkaline phosphatase, serum total bilirubin and other indicators of review time, the experimental group were significantly shorter than the reference group (P <0.05), the difference between the groups was statistically significant. Conclusion The effect of diammonium glycyrrhizinate used in the clinical treatment of acute drug-induced liver injury is very satisfactory. It has extremely significant advantages in controlling the disease, improving the therapeutic effect, shortening the course of disease, improving the liver function and improving the quality of life. It is worth popularizing.