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目的:讨论并分析对于重症感染性休克患者行多巴胺和去甲肾上腺素对其血乳酸清除率和死亡率的影响。方法:选取我院2012年11月~2014年9月期间收治的60例重症感染性休克患者为研究对象,采用随机分组的方法将60例患者平均分为多巴胺组和去甲肾上腺素组,然后就两组患者的血乳酸水平及24h乳酸清除率、平均动脉压、心率和死亡率进行综合性的比较和分析。结果:两组患者死亡率比较,去甲肾上腺素组患者明显低于多巴胺组(P<0.05),两组患者治疗前后的心率比较,差异有显著统计学意义(P<0.05);两组患者平均动脉压治疗前后比较,差异无显著统计学意义(P>0.05),治疗后血乳酸水平比较,去甲肾上腺组高于多巴胺组,差异有显著统计学意义(P<0.05)。结论:在重症感染性休克患者的治疗中,采用去甲肾上腺素进行治疗能够有效降低心率并提高患者的血乳酸清除率和患者的死亡率,临床效果显著。
OBJECTIVE: To discuss and analyze the effect of dopamine and norepinephrine on blood lactate clearance and mortality in patients with severe septic shock. Methods: Sixty patients with severe septic shock in our hospital from November 2012 to September 2014 were selected as study subjects. Sixty patients were equally divided into dopamine group and norepinephrine group by random grouping method. On the two groups of patients with blood lactate levels and 24h lactic acid clearance, mean arterial pressure, heart rate and mortality for a comprehensive comparison and analysis. Results: Compared with the dopamine group, the norepinephrine group had significantly lower mortality (P <0.05). There was a significant difference in heart rate between the two groups before and after treatment (P <0.05) There was no significant difference in mean arterial pressure before and after treatment (P> 0.05). After treatment, blood lactic acid level was higher in noradrenal gland than in dopamine group, the difference was statistically significant (P <0.05). CONCLUSIONS: Ninrenaline is effective in lowering heart rate and improving blood lactate clearance and patient mortality in patients with severe septic shock. The clinical outcome is significant.