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目的探讨CDH1基因启动子160C/A编码区单核苷酸多态性(cSNP)和浅表性膀胱移行细胞癌(STCCB)的复发之间的关系。方法健康对照组50例,无复发STCCB组33例,复发STCCB组28例,其中复发组按复发后有无临床分期和病理分级的升高分为进展组(10例)和非进展组(18例);PCRRFLP技术检测各组样本CDH1基因启动子160位点基因型。结果复发STCCB组该位点A等位基因频率(0.66)高于无复发STCCB组(0.48),P<0.05,差异有统计学意义;携带A等位基因的STCCB患者治疗后复发的危险性高于C等位基因携带者,OR值3.54,95%CI为1.52～5.73。结论CDH1基因启动子160A等位基因与浅表性膀胱移行细胞癌的复发密切相关。
Objective To investigate the relationship between the single nucleotide polymorphism (cSNP) in the coding region of CDH1 gene promoter 160C / A and the recurrence of superficial bladder transitional cell carcinoma (STCCB). Methods Fifty cases of healthy control group, 33 cases of non-recurrent STCCB group and 28 cases of recurrent STCCB group were divided into progressive group (n = 10) and non-progressive group (18 cases) according to clinical stage and pathological grade Cases); PCRRFLP technology samples of each sample CDH1 promoter 160 genotypes. Results The frequency of allele A (0.66) in STCCB group was significantly higher than that in STCCB group (0.48) (P <0.05), and the difference was statistically significant. The risk of recurrence in STCCB patients with A allele was high In C allele carriers, OR was 3.54 and 95% CI was 1.52-5.73. Conclusion The 160A allele of CDH1 promoter is closely related to the recurrence of superficial bladder transitional cell carcinoma.