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目的探讨血压变化对老龄自发性高血压大鼠(SHR)腹侧前列腺增殖的影响。方法SHR给药组在出生1个月后即开始按每天100mg/kg给予喂食卡托普利,并设SHR对照组和正常血压对照组(WKY),每组各5只。间接测量尾动脉收缩压(SBP)。分别在6月龄时、12月龄时处死动物,计算腹侧前列腺重量月增长率和前列腺指数,常规病理检查。结果SHR对照组SBP随月龄增加而上升,在SHR给药组,SBP经大剂量卡托普利治疗后得以控制,但仍高于WKY组。1月龄时,SHR和WKY腹侧前列腺重量平均值分别为186.2mg和130.0mg,6月龄时SHR给药组、SHR对照组及WKY组前列腺重量月增长率(mg/月)分别为25.63±3.59、42.76±14.4和48.26±4.5,12月龄时分别为16.53±1.43、23.32±2.15和28.61±3.99,6月龄或12月龄时SHR给药组前列腺重量月增长率低于同龄SHR对照组及WKY组(P<0.05)。6月龄时SHR给药组、SHR对照组及WKY组前列腺指数(mg/g)分别为1.01±0.09、1.12±0.14和0.93±0.07,12月龄时分别为0.95±0.06、1.11±0.05和0.96±0.09;12月龄的老年SHR给药组的指数明显低于同龄SHR对照组(P<0.05),与同龄WKY组接近(P>0.05);而SHR对照组指数在成年或老年期均高于WKY组(P<0.05)。结论高血压促进SHR BPH的发生发展,早期给予大剂量卡托普利控制血压可延缓SHR发生BPH的进程。
Objective To investigate the effect of blood pressure on the proliferation of ventral prostate in aged spontaneously hypertensive rats (SHR). Methods SHR group was fed with captopril 100 mg / kg daily after 1 month of birth, and SHR control group and normal blood pressure control group (WKY), 5 rats in each group. Indirect measurement of caudal systolic pressure (SBP). Animals were sacrificed at 6 months of age and 12 months of age respectively. The monthly rate of growth of the prostate and the prostate index were calculated, and routine pathological examination was performed. Results SBP in SHR control group increased with the increase of age. In SHR administration group, SBP was controlled by high-dose captopril, but still higher than WKY group. At 1 month of age, the average weight of the ventral prostate of SHR and WKY was 186.2 mg and 130.0 mg, respectively. The monthly rates of weight gain (mg / month) in SHR administration group, SHR control group and WKY group at 6 months of age were 25.63 ± 3.59, 42.76 ± 14.4 and 48.26 ± 4.5, at 12 months of age, 16.53 ± 1.43, 23.32 ± 2.15 and 28.61 ± 3.99, 6 months or 12 months of age SHR administration group prostate weight monthly growth rate was lower than the same age SHR Control group and WKY group (P <0.05). At 6 months, the prostate index (mg / g) in SHR administration group, SHR control group and WKY group were 1.01 ± 0.09, 1.12 ± 0.14 and 0.93 ± 0. 07, respectively, at 12 months of age, they were 0.95 ± 0.06,1.11 ± 0.05 and (P <0.05), which was similar to that of the WKY group (P> 0.05), while the index of SHR control group was significantly lower in the adult or the elderly than in the SHR control group Higher than WKY group (P <0.05). Conclusions Hypertension promotes the development of SHR and BPH. Early administration of high-dose captopril can delay the progression of BPH in SHR.