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阳萎是一种最常见的男子性功能障碍,其发病率约为10％。对各种不同病因阳萎的治疗,阴茎海绵体内注射血管活性药物(简称海绵体内注药)的有效率为70～90％。最常用的药物为罂粟碱、前列腺素E_1或罂粟碱和酚妥拉明混合剂。罂粟碱是一种强有力的平滑肌松弛剂,可使动脉扩张,海绵体小梁平滑肌松弛、部分静脉闭合。酚妥拉明是通过α-受体肾上腺能阻滞作用而扩张血管,这两种药物注入海绵体内可迅速增加血流,使阴茎勃起,对大部分阳萎者可达到满意的性交。但是应用海绵体内注药亦有一定的副作用与并发症,本文对此问题作一综述,以供参考。
Impotence is the most common form of male sexual dysfunction with a prevalence of about 10%. The treatment of various causes of impotence, penile injection of vasoactive drugs (referred to as intracavernous injection), the effective rate of 70 to 90%. The most commonly used drugs are papaverine, prostaglandin E_1 or papaverine and phentolamine admixture. Papaverine is a potent smooth muscle relaxant, can make arteries dilate, sponge trabecular smooth muscle relaxation, partial vein closure. Phentolamine dilates blood vessels through the alpha-adrenergic blockade. Both drugs are injected into the cavernous body to rapidly increase blood flow and erect the penis. Satisfactory sexual intercourse can be achieved for most impotence. However, the application of cavernosal injection of drugs also have some side effects and complications, this paper reviews the issue for reference.