论文部分内容阅读
目的 探讨狼疮性肾炎早期临床表现、生化与病理指标与患者 5年肾功能稳定率的关系 ,为指导临床预后判断和治疗提供依据。方法 采用COX比例风险模型 ,对 5 5例狼疮性肾炎的临床、生化、病理资料进行预后分析。结果 病程初期的 2 4h尿蛋白定量越高 ,间质炎症、小管萎缩、间质纤维化病变越严重 ,慢性病变越严重 ,则肾功能恶化危险性越大。结论 2 4h尿蛋白定量、间质炎症、间质纤维化程度及小管萎缩 ,是能够提示狼疮性肾炎 5年肾功能稳定率的有用指标
Objective To investigate the relationship between early clinical manifestations, biochemical and pathological indexes of patients with lupus nephritis and the 5-year stability of renal function in patients with lupus nephritis, and to provide evidence for guiding the clinical prognosis judgment and treatment. Methods Fifty-five patients with lupus nephritis were enrolled in this study. The clinical, biochemical and pathological data of 55 patients with lupus nephritis were analyzed retrospectively. Results In the early stage of the course of disease, the higher the quantitative urinary protein at 24 hours, the more interstitial inflammation, tubule atrophy, the more severe the interstitial fibrosis and the more severe chronic disease, the greater the risk of renal dysfunction. Conclusions 24 h urinary protein quantitation, interstitial inflammation, interstitial fibrosis and tubular atrophy are useful indicators of 5-year renal stability after lupus nephritis