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目的:观察低分子肝素(LMWH)和普通肝素(UFH)在主动脉内球囊反搏术(IABP)中抗凝应用的临床效果。方法:68例安置IABP的患者随机分为应用UFH抗凝的常规组(34例)和应用LMWH抗凝的试药组(34例),观察两组患者的出血、血肿、血栓形成等并发症发生情况及费用差别。结果:两组均只有少部分患者有伤口少量渗血、局部小血肿和伤口周围轻度青紫等表现,无其它并发症出现,两组比较差异无显著性。但试药组的费用比常规组低,两组比较差异有显著性。结论:在IABP中应用LMWH可以达到应用UFH相同的抗凝、预防血栓形成的效果,同时并发症无增加,而费用减少。
Objective: To observe the clinical effect of low molecular weight heparin (LMWH) and unfractionated heparin (UFH) on anticoagulation in intra-aortic balloon pump (IABP). Methods: Sixty-eight patients with IABP were randomly divided into the conventional group (34 cases) treated with UFH anticoagulation and the test group (34 cases) treated with LMWH anticoagulation. The bleeding, hematoma and thrombosis were observed in two groups Occurrence and cost differences. Results: Only a small part of the patients in both groups had small bleeding, small hematoma and mild bruising around the wound. No other complications occurred. There was no significant difference between the two groups. However, the cost of the test group was lower than that of the conventional group, and the difference between the two groups was significant. CONCLUSIONS: The use of LMWH in IABP can achieve the same anticoagulation and thrombotic effect with UFH, with no increase in complications and a reduction in cost.