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目的研究血清超敏C-反应蛋白(hs-CRP)与老年冠心病严重程度的关系。方法选择2005年10月至2006年12月在汕头大学医学院第一附属医院心血管病房住院的患者共128例。测定经冠状动脉造影确诊的110例老年冠心病患者血清hs-CRP浓度,其中稳定型心绞痛患者40例,不稳定型心绞痛患者58例,急性心肌梗死患者12例。以经冠状动脉造影排除冠心病的18例患者为正常对照组,比较各组间hs-CRP的浓度。结果冠心病患者各亚组hs-CRP的浓度均较正常对照组(0.58±0.27)mg/L显著升高,P<0.01。冠心病患者各亚组中,不稳定型心绞痛组血清hs-CRP的浓度(7.78±5.93)mg/L显著高于稳定型心绞痛组(5.46±10.7)mg/L,P<0.01;急性心肌梗死组血清hs-CRP的浓度(32.75±22.12)mg/L,显著高于不稳定型心绞痛组及稳定型心绞痛组,P<0.01。结论血清hs-CRP的浓度与冠心病患者病情的严重程度有关,可作为临床冠心病患者病情严重程度的参考指标。
Objective To study the relationship between serum hs-CRP and the severity of coronary heart disease in elderly. Methods A total of 128 patients admitted to the Cardiology Hospital of the First Affiliated Hospital of Shantou University Medical College from October 2005 to December 2006 were selected. Determination of serum hs-CRP levels in 110 elderly patients with coronary heart disease diagnosed by coronary angiography, including 40 patients with stable angina pectoris, 58 patients with unstable angina pectoris, and 12 patients with acute myocardial infarction. Eighteen patients who had coronary artery disease underwent coronary angiography were selected as the normal control group, and the concentration of hs-CRP in each group was compared. Results The concentration of hs-CRP in each subgroup of patients with CHD was significantly higher than that of the control group (0.58 ± 0.27) mg / L, P <0.01. The serum concentration of hs-CRP in unstable angina group (7.78 ± 5.93) mg / L was significantly higher than that in stable angina group (5.46 ± 10.7) mg / L in all subgroups of patients with coronary heart disease, P <0.01; acute myocardial infarction The concentration of serum hs-CRP in the group (32.75 ± 22.12) mg / L was significantly higher than that in unstable angina group and stable angina pectoris group (P <0.01). Conclusions The serum hs-CRP concentration is related to the severity of coronary heart disease and can be used as a reference index for the severity of clinical coronary heart disease.