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Objective:To study the diagnostic and therapeutic features of prolactinoma.Methods:124 patients with prolactinoma were studied in clinical manifestation,pathologic,endocrinological,radiographic and therapeutic features.Results:The average age of the male patients was 41.6 years,32.3 years of females.The major clinical manifestation in males were sexual and visual disfunction.In females,disfunction of menstruates and galactorrhea.Average serum prolactin was 1875.22 in males,376.6 ng/mL in females.Average diameter of the tumors was 38.05 mm in males,and 83.3% of the tumors were invasive,in females were 15.25 mm and 49%.After surgery,the average serum prolactin decreased to 385.84 ng/mL (P＜0.05),13 of 15 patients improved in sexual function,82.6% patients improved in eyesight and visual field.In females prolactin decreased to 23.93 ng/mL (P＜0.05),and 81 25% infertility with microprolactinoma got pregnancy,higher than controls of drugtherapy (P＜0.05).Conclusion:In males,the tumors were usually larger and more invasive,and serum prolactin levels were higher.The patients were elder.But in females,much younger than males,most of the tumors were microadenoma,and after operation the prolactin usually decrease to normal level and more chance of pregnancy.Results of a single therapy were with less satisfaction,we advocate integrated therapy around operation.