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目的:探讨喉鳞癌患者血清中内皮抑素水平的变化,及其与肿瘤临床分期及预后的关系。方法:(1)对50例喉鳞癌患者、30例喉息肉患者和30例健康人用ELISA方法检测血清中内皮抑素水平;(2)对喉鳞癌组不同临床分期的血清中内皮抑素的水平进行比较。结果:(1)喉鳞癌组血清中内皮抑素水平(51.45±19.83ng/mL),显著高于喉息肉组(34.56±12.41ng/mL)和正常对照组(33.12±13.04ng/mL),差别有统计学意义(P<0.01)。喉息肉组与正常对照组之间差别无显著性(P>0.05)。(2)II期喉鳞癌患者血清内皮抑素的水平(66.22±10.89ng/mL)高于I、II期患者内皮抑素水平(39.31±14.42ng/mL,47.98±22.01ng/mL),差别有统计学意义(P<0.01),I期与II期之间内皮抑素水平差别无显著性(P>0.05)。结论:内皮抑素含量水平可以作为喉鳞癌的诊断及预后判断的重要指标之一。
Objective: To investigate the change of serum endostatin levels in patients with laryngeal squamous cell carcinoma and its relationship with the clinical stage and prognosis. Methods: (1) Serum endostatin levels were measured in 50 patients with laryngeal squamous cell carcinoma, 30 patients with laryngeal polyps and 30 healthy controls by ELISA. (2) The serum levels of endostatin The levels of primes are compared. Results: (1) The serum level of endostatin (51.45 ± 19.83ng / mL) in laryngeal squamous cell carcinoma group was significantly higher than that in larynx polyp group (34.56 ± 12.41ng / mL) and normal control group (33.12 ± 13.04ng / mL) , The difference was statistically significant (P <0.01). There was no significant difference between laryngeal polyp group and normal control group (P> 0.05). (2) The level of serum endostatin in patients with stage II laryngeal squamous cell carcinoma (66.22 ± 10.89ng / mL) was higher than that in stage I and II patients (39.31 ± 14.42ng / mL, 47.98 ± 22.01ng / mL) The difference was statistically significant (P <0.01). There was no significant difference in the endostatin level between stage I and stage II (P> 0.05). Conclusion: The level of endostatin can be used as an important index for diagnosis and prognosis of laryngeal squamous cell carcinoma.