Poly(propylene fumarate-co-propylene sebacate) (P(PF-co-PS)) was crosslinked with N-vinyl pyrrolidone (N-VP) to form networks. It was investigated as biodegradable bone cement. In this paper, P(PF-co-PS) was synthesized and characterized by1 H-NMR, FTIR and GPC. The effects of the amount of sebacate segments in P(PF-co-PS) main chains and the quantity of N-vinyl pyrrolidone on the in vitro degradation of the polymer networks were examined. Cylindrical specimens were submerged in phosphate buffered saline (PBS) at 37 ℃ and the pH value of PBS is 7.4 for 10 weeks. The gravimetry and compressive mechanical properties were tested over the degradation period. Networks formed by P(PF-co-PS)8020/N-VP exhibited higher weight loss and better mechanical properties when compared with poly(propylene fumarate)/N-VP networks. The mechanical properties of P(PF-co-PS)/N-VP can be maintained for a very long time, even for 70 days, the yield strength, fracture strength and compressive modulus are (51.78 ± 2.01) MPa, (52.331 ± 1.84) MPa and (957.78 ± 24.40) MPa, respectively. The results demonstrate that the compressive mechanical properties and degradation velocity can be modulated by the amount of crosslinking agents and sebacate segments along the main chains of copolymers. Poly (propylene fumarate-co-propylene sebacate) was crosslinked with N-vinyl pyrrolidone (N-VP) to form networks. It was investigated as biodegradable bone cement. In this paper, P PF-co-PS) was synthesized and characterized by1H-NMR, FTIR and GPC. The effects of the amount of sebacate segments in P (PF-co-PS) main chains and the quantity of N-vinyl pyrrolidone on the in vitro degradation of the polymer networks were examined. Cylindrical specimens were submerged in phosphate buffered saline (PBS) at 37 ° C and the pH value of PBS was 7.4 for 10 weeks. The gravimetry and compressive mechanical properties were tested over the degradation period. Networks formed by P (PF-co-PS) 8020 / N-VP shows higher weight loss and better mechanical properties when compared with poly (propylene fumarate) / N-VP networks. The mechanical properties of P (PF-co-PS) VP can be maintained for a very long time, even for 70 days, the yield strength, fracture strength and compressive modulus are (51. 78 ± 2.01) MPa, (52.331 ± 1.84) MPa and (957.78 ± 24.40) MPa, respectively. The results demonstrate that the compressive mechanical properties and degradation velocity can be modulated by the amount of crosslinking agents and sebacate segments along the main chains of copolymers.