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目的建立糖皮质激素诱导的老年小鼠骨质疏松模型，探讨以单位体积的钙重量变化来反映骨质疏松状况。方法老年小鼠按不同剂量每周肌注地塞米松２次（高剂量组０．００５ｍｇ／ｇ；中剂量组０．００１ｍｇ／ｇ；低剂量组０．０００５ｍｇ／ｇ），实验第１２周末时，采用排水法测量小鼠右侧股骨体积，采用化学方法测量小鼠骨钙。结果对照组骨钙含量（０．２２１５±０．０２３６ｇ／ｃｍ３）较中等剂量组（０．１６９８±０．２４００ｇ／ｃｍ３）高（Ｐ＜０．０１），与低剂量组（０．２１１９±０．０２１５ｇ／ｃｍ３）其差异无显著性（Ｐ＞０．０５）。结论该动物模型及单位体积的钙重量表达方式可应用于实验研究。
Objective To establish an animal model of osteoporosis induced by glucocorticoids and to explore the status of osteoporosis by measuring the change of calcium per unit volume. Methods Elder mice were intramuscularly injected with dexamethasone twice a week (high dose 0.005mg / g; middle dose 0.001mg / g; low dose 0.0005mg / g) at the end of the twelfth week , Using the drainage method to measure the volume of right femur in mice and measuring the calcium in mice by chemical method. Results The content of calcium in the control group (0.2215 ± 0.0236g / cm3) was significantly higher than that in the medium dose group (0.1698 ± 0.2400g / cm3) (P <0.01) 0.0215g / cm3) the difference was not significant (P> 0.05). Conclusion The animal model and the unit volume of calcium weight expression can be applied to experimental study.