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目的探讨维A酸与塞来昔布联合用药治疗口腔白斑的治疗方法和临床疗效。方法将2009年1月至2012年6月确诊为口腔白斑的160例患者随机分为研究组和对照组,每组80例。对照组给予口服维生素A 25 U/次,维生素E 0.1万U/次,3次/d;塞来昔布胶囊100 mg/次,每日2次;3个月为1个疗程,治疗2个疗程。研究组在对照组治疗基础上额外给予维A酸软膏涂抹患处,每日2次。对比两组患者治疗效果、病理结果和癌变率。结果研究组患者治疗总有效率为96.25%,显著高于对照组的77.50%(P<0.01);病理情况显著优于对照组(P<0.01);治疗2年后癌变率(1.25%)显著低于对照组的8.75%(P<0.05)。结论维A酸联合塞来昔布治疗口腔白斑可有效改善口腔白斑患者的临床症状并预防癌变的发生。
Objective To investigate the treatment of oral leukoplakia with vitamin A acid and celecoxib and its clinical efficacy. Methods 160 patients diagnosed as oral leukoplakia from January 2009 to June 2012 were randomly divided into study group and control group, 80 cases in each group. The control group was given oral vitamin A 25 U / times, vitamin E 0.1 million U / times, 3 times / d; celecoxib capsules 100 mg / time 2 times a day; 3 months for a course of treatment of 2 Course of treatment. The study group in the control group based on the treatment of extra retinoid acid ointment applied to the affected area, 2 times a day. Comparison of two groups of patients treatment, pathological results and cancer rates. Results The total effective rate was 96.25% in the study group, which was significantly higher than that in the control group (77.50%, P <0.01). The pathological condition was significantly better than that in the control group (P <0.01) Lower than 8.75% of the control group (P <0.05). Conclusion Tretinoin combined with celecoxib in the treatment of oral leukoplakia can effectively improve the clinical symptoms of oral leukoplakia and prevent the occurrence of carcinogenesis.