论文部分内容阅读
目的:探讨胃癌患者外周血CD4+CD25+调节性T细胞的变化及临床意义。方法:应用流式细胞仪检测52例胃癌患者(胃癌组)和24例健康对照者(健康组)的CD4+CD25+调节性T细胞水平。结果:胃癌组外周血CD4+CD25+调节性T细胞较健康组明显升高,胃癌Ⅲ+Ⅳ期患者外周血CD4+CD25+调节性T细胞水平比Ⅰ+Ⅱ患者明显升高。结论:胃癌患者外周血CD4+CD25+调节性T细胞水平明显升高,可能是机体免疫功能受抑制的重要机制,并可成为胃癌患者机体免疫状态临床监测的指标。
Objective: To investigate the changes and clinical significance of CD4 + CD25 + regulatory T cells in peripheral blood of patients with gastric cancer. Methods: The levels of CD4 + CD25 + regulatory T cells in 52 patients with gastric cancer (GC group) and 24 healthy controls (healthy group) were detected by flow cytometry. Results: The percentage of CD4 + CD25 + regulatory T cells in peripheral blood of gastric cancer patients was significantly higher than that of healthy patients. The levels of CD4 + CD25 + regulatory T cells in patients with stage Ⅲ + Ⅳ gastric cancer were significantly higher than those in patients with Ⅰ + Ⅱ. Conclusion: The level of CD4 + CD25 + regulatory T cells in peripheral blood of patients with gastric cancer is significantly increased, which may be an important mechanism of inhibition of immune function and may become an index of clinical monitoring of the immune status of gastric cancer patients.