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目的 检测甲状腺功能亢进(甲亢)患者血清中血管内皮生长因子(vascularendothelialgrowthfac tor,VEGF)含量的变化,分析其异常原因及临床意义。同时观察血清TSH水平与VEGF的相关性。方法 运用 酶法分别对甲亢组47例,正常组45例血清中VEGF水平进行检测,运用RIA方法对血清TSH水平测定。结果 甲亢组血清中VEGF水平为(79.1±12.8)pg/ml,明显高于正常对照组(44.73±11.7)pg/ml。经t检验,两组差异 有非常显著性意义(P<0.01)。经过直线回归,VEGF和TSH有良好的相关性,可以结合起来测定以判断患者的 甲亢的严重程度。结论 甲亢患者血清中VEGF含量的检测,对临床甲亢疾病的诊断、治疗及预后有着重要的指 导意义。
Objective To investigate the changes of serum vascular endothelial growth factor (VEGF) levels in patients with hyperthyroidism (Hyperthyroidism) and to analyze the causes and clinical significance of the abnormalities. At the same time, the correlation between serum TSH level and VEGF was observed. Methods Serum levels of VEGF in 47 cases of hyperthyroidism group and 45 cases of normal group were detected by enzymatic method. Serum TSH levels were determined by RIA method. Results The level of VEGF in serum of hyperthyroidism group was (79.1 ± 12.8) pg / ml, which was significantly higher than that of the normal control group (44.73 ± 11.7) pg / ml. After t test, there was a significant difference between the two groups (P <0.01). After a straight-line regression, VEGF and TSH have a good correlation and can be combined to determine the severity of hyperthyroidism in patients. Conclusion The detection of serum VEGF in patients with hyperthyroidism has an important guiding significance in the diagnosis, treatment and prognosis of clinical hyperthyroidism.