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细胞恶性转化经常伴随着1号染色体的畸变。在人类恶性血液病及实体瘤中都发现这种情况。与1号染色体有关的人类肿瘤分布十分广泛,这提示他们并非是恶变的起因,而有可能是继发的,并在克隆演化中出现。本文根据FAB分类法报道1例L_2型急性淋巴细胞白血病(ALL)患者的细胞遗传学研究。在患者确诊治疗前,对恶性细胞进行细胞遗传学分析。不加丝裂原,外周血经24小时培养,标本用GTG和CBG显带法识别染色体。此外还对患者淋巴细胞经PHA刺激进行常规分析,决定其核型。
Malignant transformation of cells is often accompanied by aberrations on chromosome 1. This has been found in human hematological malignancies and solid tumors. Human tumors associated with chromosome 1 are widely distributed, suggesting that they are not the cause of malignancy, but may be secondary and occur during clonal evolution. According to the FAB classification method, we report a cytogenetic study of a patient with L2 acute lymphoblastic leukemia (ALL). Cytogenetic analysis of malignant cells was performed before patients were diagnosed with treatment. Without mitogen, peripheral blood was cultured for 24 hours and the specimens were identified by GTG and CBG banding. In addition, lymphocyte lymphocytes were routinely analyzed by PHA stimulation to determine their karyotype.