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目的 探讨幽门螺杆菌 (Hp)感染及慢性萎缩性胃窦炎伴肠上皮化生与CD4 4V6表达程度之间的关系。方法 以单克隆抗体及免疫组化技术等方法对Hp阴性单纯慢性胃炎、Hp阴性萎缩性胃炎伴肠上皮化生、Hp阳性萎缩性胃窦炎伴肠上皮化生、胃窦腺癌的胃镜下活检组织标本进行测定分析。结果 在Hp阴性单纯性胃炎组粘膜上皮未见CD4 4V6表达 ,Hp阴性萎缩性胃窦炎伴肠上皮化生、Hp阳性萎缩性胃窦炎伴肠上皮化生、胃窦腺癌各组CD4 4V6表达程度依次逐渐升高 ,各组之间比较差异有显著性 (P <0 .0 5 )。结论 CD4 4V6的表达可能是上皮细胞癌前病变出现的早期生物学信号 ,肠上皮化生细胞可能诱导CD4 4V6的表达 ,而Hp感染则有促进这种诱导表达的作用。
Objective To investigate the relationship between Helicobacter pylori (Hp) infection and chronic atrophic gastritis with intestinal metaplasia and CD4 (4) V6 expression. Methods Monoclonal antibody and immunohistochemical methods such as Hp-negative chronic gastritis, Hp-negative atrophic gastritis with intestinal metaplasia, Hp-positive atrophic gastritis with intestinal metaplasia, gastric adenocarcinoma under endoscopy Biopsy specimens were measured and analyzed. Results There was no expression of CD4 4V6 in mucosal epithelium of Hp-negative gastritis patients, Hp-negative atrophic gastritis with intestinal metaplasia, Hp-positive atrophic gastritis with intestinal metaplasia, gastric adenocarcinoma in each group CD4 4V6 The expression levels gradually increased, with significant differences between the groups (P <0.05). Conclusion The expression of CD4 4V6 may be an early biological signal of precancerous lesions of epithelial cells. The intestinal metaplastic cells may induce the expression of CD4 4V6, while Hp infection may promote the induction of this expression.