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目的:通过meta分析评价miRNA-146a rs2910164位点基因多态性与肝癌易感性之间的相关性。方法:系统地检索Pub Med、Embase、Web of Science、中国知网以及中国生物医学文献数据库2017年1月30日之前发表的相关文章,用总的比值比(odd ratios,OR)及相应的95%可信区间(credibility intervals,CI)来评价miRNA-146a基因多态性与肝癌易感性之间的相关性。结果:共纳入了18项病例对照研究,包括5 657例肝癌病例与6 680例健康对照。经过统计分析未发现miRNA-146a rs2910164位点的基因多态性与肝癌易感性之间存在相关性(C vs.G:OR=0.96,95%CI=0.88~1.06;GC vs.GG:OR=0.98,95%CI=0.88~1.09;CC vs.GG:OR=0.90,95%CI=0.74~1.09;GC/CC vs.GG:OR=0.95,95%CI=0.82~1.10;CC vs.GC/GG:OR=0.95,95%CI=0.84~1.07)。结论:目前没有足够证据能够证明miRNA-146a基因多态性与肝癌易感性之间存在相关性。未来有必要在大规模和设计完善的研究中加以验证。
OBJECTIVE: To evaluate the association between miRNA-146a rs2910164 polymorphism and susceptibility to hepatocellular carcinoma by meta-analysis. Methods: PubMed, Embase, Web of Science, CNKI, and Chinese Biomedical Literature Database were searched for articles published before January 30, 2017. The odds ratio (OR) and corresponding 95 % Credibility intervals (CI) to evaluate the relationship between miRNA-146a polymorphism and susceptibility to HCC. RESULTS: A total of 18 case-control studies were included, including 5,657 HCC cases and 6,680 healthy controls. After statistical analysis, there was no correlation between miRNA-146a rs2910164 gene polymorphism and susceptibility to hepatocellular carcinoma (C vs. G: OR = 0.96, 95% CI = 0.88-1.06; GC vs.GG: OR = 0.98, 95% CI = 0.88 to 1.09; CC vs.GG: OR = 0.90, 95% CI = 0.74 to 1.09; GC / CC vs.GG: OR = 0.95, 95% CI = 0.82 to 1.10; /GG:OR=0.95,95%CI=0.84~1.07). Conclusion: There is not enough evidence to show the correlation between miRNA-146a gene polymorphism and susceptibility to liver cancer. The future needs to be validated in large-scale and well-designed studies.