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1994年,在儿童疫苗计划范围内,世界卫生组织(WHO)/联合国开发计划署(UNDP)将资助下列重点领域的研究项目。研究计划必须在截止期以前送达。 疾病特异性疫苗学 一、细菌性和病毒性腹泻(截止期:1994年3月15日) (一)志贺菌、霍乱、产肠毒素性大肠杆菌和伤寒菌苗:口服死菌苗;减毒活菌株或活载体菌苗;免疫力的体外相关因子;新出现的霍乱弧菌O139株菌苗。 (二)轮状病毒疫苗:确定保护作用的免疫学相关因子;研制候选亚单位疫苗和轮状病毒减毒株;活病毒和细菌载体疫苗;合适的动物模型。 二、脑膜炎球菌性脑膜炎和肺炎球菌性肺炎(截止期:1994年2月15日) 研制新型A/C群脑膜炎球菌结合菌苗、B群脑膜炎球菌菌苗和有关的基础研
In 1994, within the framework of the Childhood Vaccine Initiative, WHO / UNDP will fund research projects in the following priority areas. The research plan must be served by the deadline. Disease-specific vaccine First, the bacterial and viral diarrhea (deadline: March 15, 1994) (a) Shigella, cholera, enterotoxigenic Escherichia coli and typhoid vaccine: oral killed vaccine; minus Live virulent strains or live carrier vaccines; Immunity in vitro related factors; Emerging V. cholerae O139 strain vaccine. (B) of the rotavirus vaccine: to determine the protective effect of immune-related factors; development of candidate subunit vaccine and rotavirus attenuated strains; live virus and bacterial vector vaccines; appropriate animal models. Second, meningococcal meningitis and pneumococcal pneumonia (deadline: February 15, 1994) to develop a new group of A / C meningococcal conjugate vaccine, meningococcal group B vaccine and related basic research