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目的为探讨全身炎症反应综合征（ＳＩＲＳ）诊断标准与临床应用的可行性。方法将ＡＣＣＰ／ＳＣＭＭ标准做了相应的修订，其中心率＞９０次／ｍｉｎ和呼吸＞２０次／ｍｉｎ，分别修订为心率＞１００次／ｍｉｎ和呼吸＞２２次／ｍｉｎ。分析我院１９９５年１０月～１９９６年７月１０个月１０２５例ＳＩＲＳ的临床资料，病人至少符合修订后２项以上ＳＩＲＳ标准，包括发热、体温过低、心动过速、呼吸急促或白细胞计数异常。结果共观察病人１９０９例，其中１０２５例（５３７％）符合修订后２项或２项以上ＳＩＲＳ标准。１０２５例中符合２项ＳＩＲＳ标准者３８１例（３７２％），３项者３９５例（３８５％），４项者２４９例（２４３％）。１０２５例中死亡１４２例（２３８％），其中符合２项标准者死亡２０例（７８％），３项者死亡５５例（２３９％），４项者死亡５７例（２２９％），病死率随ＳＩＲＳ项数增加而升高，２项与３项、２项与４项、３项与４项比较均相差非常显著（Ｐ＜００１）。死亡者增多并发多器官功能障碍综合征（ＭＯＤＳ），随着病情发展ＳＩＲＳ的项数增加及ＳＩＲＳ发展为ＭＦＤ、ＡＲＤＳ、ＡＲＦ和ＤＩＣ的例数也增加，合并症随ＳＩＲＳ项数增加而升高（Ｐ?
Objective To investigate the diagnostic criteria and clinical feasibility of systemic inflammatory response syndrome (SIRS). Methods The ACCP / SCMM standard was revised with heart rate> 90 beats / min and breath> 20 beats / min, which were revised to heart rate> 100 beats / min and respiration> 22 beats / min. The clinical data of 1025 SIRS patients in our hospital from October 1995 to July 1996 were analyzed. The patients met at least two revised SIRS criteria including fever, hypothermia, tachycardia, shortness of breath or abnormal white blood cell count . Results A total of 1909 patients were observed. Among them, 1025 (53.7%) patients met the revised SIRS criteria of 2 or more. Among 1025 cases, 381 (372%) were eligible for 2 SIRS criteria, 395 (385%) were 3 items, and 249 (243%) were 4 items. Among 1025 cases, 142 died (23.8%), of whom 20 (78%) died in 2 criteria, 55 (239%) died in 3 items and 57 (4%) died in 22 items 9%). The case fatality rate increased with the increase of SIRS number. The difference between 2 and 3, 2, 4, 3 and 4 was significant (P <001). The number of deaths increased in patients with multiple organ dysfunction syndrome (MODS). The number of cases with ARDS, ARF and DIC increased as the number of SIRS items increased and the SIRS progressed to MFD. The comorbidity increased with the increase of SIRS items (P?