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目的 研究经肝动脉介入热疗对荷瘤兔肝肾功能及生命体征的影响 ,探讨介入热疗治疗肿瘤的安全性 .方法 建立可供实验研究的兔 VX2 移植性肝癌模型 10只 ;30 min内经兔肝动脉缓慢匀速注入 6 0℃生理盐水 4 0 m L .分别于灌注前及灌注后 1,3,5和 7d检查肝、肾功的动态变化情况 .结果 荷瘤兔的呼吸、心率、体温都有一定程度的改变 ,但 1h内均可恢复正常 ;AL T,AST于灌注后开始升高 (AL T7倍 ,AST2倍 ) ,之后逐渐恢复 ,1wk后恢复正常 ;胆红素、白蛋白及γ- GT无明显变化 .对肾功指标的监测表明 ,热疗对肾脏无明显影响 .结论 介入性热疗对荷瘤兔生命体征及肝肾功的影响是轻度的、可逆的 ,可以耐受 .
Objective To study the effect of interventional hyperthermia on hepatic and renal function and vital signs in tumor-bearing rabbits and to discuss the safety of interventional hyperthermia in the treatment of tumor.Methods To establish 10 experimental models of rabbit VX2 transplanted liver cancer, Rabbit hepatic artery was injected slowly and homogeneously into normal saline at 60 ℃ for 40 min before and at 1, 3, 5 and 7 days after perfusion to check the dynamic changes of liver and kidney function.Results The respiration, heart rate, body temperature ALT, AST began to increase (ALT7-fold, AST2-fold) after the infusion, and then gradually recovered after 1wk; bilirubin, albumin and γ-GT no significant changes in the monitoring of renal function indicators show that no significant effect of hyperthermia on the kidneys.Conclusion Interventional hyperthermia on tumor-bearing rabbit vital signs and liver and kidney function is mild, reversible, resistant By