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非甾体抗炎药(non2 steroidal anti2inflammatory durgs,NSAID)在临床上的应用非常广泛,用于治疗类风湿性关节炎、骨关节炎及其他风湿性疾病,其常见不良反应主要有胃肠道损害、肾脏损害、肝脏以及血液等系统损害。其发生机制与抑制前列腺素合成有关,预防或减弱NSAID不良反应的措施是合理用药、避免NSAID滥用、使用胃黏膜保护剂等。今后NSAID发展的方向应是选择性COχ22抑制剂、NO释放型NSAID以及选择性COχ22/52LOX双重抑制。
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used clinically to treat rheumatoid arthritis, osteoarthritis and other rheumatic diseases. The common adverse reactions are gastrointestinal damage , Kidney damage, liver and blood system damage. Its mechanism of inhibition of prostaglandin synthesis and prevent or reduce the adverse reactions of NSAID is the rational use of drugs to avoid abuse of NSAID, the use of gastric mucosal protective agent. Future directions for the development of NSAIDs should be dual COx22 inhibitors, NO-releasing NSAIDs and dual COx22 / 52LOX suppression.