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氟桂嗪(flunarizine, FNZ)为一种选择性钙通道阻滞剂,长期应用可缓解周围血管(动脉和静脉)和脑血管疾病的症状;还可治疗前庭功能障碍和预防偏头痛。近有报道,FNZ对癫痫和尿失禁也有疗效。本品是通过抑制Ca~(++)进入组织细胞,防止过量Ca~(++)引起的组织细胞中毒,特别是对血管平滑肌细胞、内皮细胞、心肌细胞、红细胞和脑细胞功能的影响。FNZ的结构式请参考《新药与临床》1986年第5期第299页。
Flunarizine (FNZ), a selective calcium channel blocker, has long been used to relieve symptoms of peripheral blood vessels (arteries and veins) and cerebrovascular disease. It can also treat vestibular dysfunction and prevent migraine. It has been reported recently that FNZ is also effective on epilepsy and urinary incontinence. This product is through the inhibition of Ca ~ (++) into the tissue cells, to prevent excess Ca ~ (++) caused by tissue cytotoxicity, especially on vascular smooth muscle cells, endothelial cells, cardiomyocytes, red blood cells and brain cell function. FNZ structural formula, please refer to “New Drugs and Clinical” 1986 the fifth period page 299.