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目的探讨阿仑磷酸钠联合金天格胶囊治疗Ⅱ型原发性骨质疏松(OP)的临床疗效。方法将112例Ⅱ型OP患者随机分为2组:观察组使用阿仑磷酸钠片联合金天格胶囊,同时服用碳酸钙;对照组给予阿仑磷酸钠片和碳酸钙,连续治疗6个月,记录分析2组患者治疗前后的临床疗效、骨密度(BMD)变化及碱性磷酸酶(AKP)等数据。结果 6个月后,观察组患者的临床症状改善程度优于对照组;观察组患者的BMD值增加明显(P<0.05),AKP下降显著,与对照组比较差异显著(P<0.0001)。结论阿仑磷酸钠联合金天格治疗Ⅱ型OP的效果显著,能够有效改善临床症状,明显增加骨密度,安全性好,可在临床推广应用。
Objective To investigate the clinical efficacy of alendronate combined with Jintiange Capsule in the treatment of type Ⅱ primary osteoporosis (OP). Methods One hundred and twelve patients with type Ⅱ OP were randomly divided into 2 groups: observation group were treated with alendronate sodium tablets and Jintiange capsules while taking calcium carbonate; control group were given alendronate sodium tablets and calcium carbonate, continuous treatment for 6 months The clinical efficacy, changes of bone mineral density (BMD) and alkaline phosphatase (AKP) before and after treatment were recorded and analyzed. Results Six months later, the clinical symptoms of the observation group were better than that of the control group. The BMD of the observation group increased significantly (P <0.05) and the AKP decreased significantly (P <0.0001). Conclusion The combination of sodium alendronate and Jintiange is effective in treating type Ⅱ OP, which can effectively improve the clinical symptoms, increase the bone density obviously, have good safety and can be popularized and applied clinically.