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目的对福建闽东地区畲族妇女进行宫颈人乳头状瘤病毒(HPV)亚型感染的筛查,以探讨其分布规律。方法采用核酸分子杂交分型技术,对闽东地区19～73岁有性生活的畲族妇女进行宫颈HPV基因分型检测。结果165例样本中,HPV感染者41例,整体感染率24.85%。检出10种高危型HPV(HPV-16,18,31,33,45,52,56,58,59,68)34例,感染率为20.61%(34/165例);检出4种低危型HPV(HPV-6,53,44,CP8304)7例,感染率为4.24%(7/165例)。单一亚型占78.05%(32/41例),双重或多重亚型占21.95%(9/41例),以二重感染多见。感染率居前3位的是:HPV-52(8.48%)、HPV-58(5.45%)、HPV-16(4.85%)。结论闽东地区畲族妇女HPV感染率和多重感染比例均较高,以高危型HPV52型感染最多,HPV感染亚型分布有一定的区域性,值得关注。
Objective To screen the cervical HPV infection in She ethnic women in eastern Fujian province to explore its distribution. Methods Cervical HPV genotyping was performed on shes women aged 19-73 years living in eastern Fujian province by nucleic acid hybridization. Results Of the 165 samples, 41 were HPV-infected, with an overall infection rate of 24.85%. Among the 10 high-risk HPVs (HPV-16,18,31,33,45,52,56,58,59,68), 34 cases were detected, the infection rate was 20.61% (34/165 cases) Seven cases of HPV (HPV-6, 53, 44, CP8304) were infected with the infection rate of 4.24% (7/165 cases). A single subtype accounted for 78.05% (32/41 cases), double or multiple subtypes accounted for 21.95% (9/41 cases), with double infection more common. The top three infections were HPV-52 (8.48%), HPV-58 (5.45%) and HPV-16 (4.85%). Conclusion The prevalence of HPV infection and multiple infection in She ethnic women in the east Fujian province are high. High-risk HPV52 infection and HPV subtypes distribution have certain regional distribution, which deserves attention.