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[目的] 观察白芍总苷(TGP)与雷公藤多苷对口腔扁平苔藓(OLP)患者血清白细胞介素-12(IL-12)、转化生长因子β(TGF-β)、γ-干扰素(IFN-γ)表达水平及免疫功能的影响.[方法] 回顾性分析2010年3月至2012年3月本院口腔科与皮肤科收治的OLP患者64例,根据相关临床资料和OLP患者适应证分为对照组和观察组.对照组患者口服TGP胶囊,观察组患者口服雷公藤多苷片.比较两组患者治疗后的临床疗效及治疗前后血清中IL-12、TGF-β、IFN-γ表达水平、细胞免疫指标CD4+、CD8+和CD4+/CD8+等T淋巴细胞亚群的变化.[结果] 观察组患者总有效率为84.37%(27/32),明显高于对照组65.63(21/32),其差异具有统计学意义(X2=7.682,P<0.05).观察组患者治疗后血清中IL-12和IFN-γ表达水平明显低于对照组,而TGF-β表达水平明显高于对照组,其差异有统计学意义(P<0.05).治疗后观察组患者免疫指标CD4+和CD8+均明显低于对照组,而CD4+/CD8+免疫指标明显高于对照组,其差异均有统计学意义(P<0.05).随访半年发现,观察组复发率为9.38%(3/32),明显低于对照组21.88%(7/32),其差异有统计学意义(X2=6.552,P<0.05).观察组不良反应发生率为25.00%(8/32),明显高于对照组9.38%(3/32)(X2=7.421,P<0.05).[结论] TGP与雷公藤多苷治疗口腔扁平苔藓效果显著,两者均可通过调节机体细胞免疫和影响相关细胞因子的表达及分泌来发挥作用.二药相比,雷公藤多苷治疗效果更好,但毒副作用大,为后期两者联合用药提供可能,值得进一步临床研究.“,”[Objective]To observe effects of total glucosides of paeony and tripterygium glycosides on serum IL-12, TGF-β and IFN-γ expression levels and immunologic function in patients with oral lichen planus (OLP).[Methods]The clinical data of 64 patients with OLP treated in our stomatology and dermatology divisions from March 2010 to March 2012 were retrospectively analyzed and divided into the control group and the treatment group according to the treatment method.Patients in the control group were given oral total glucosides of paeony capsules while those in the observation group were given oral tripterygium glycosides tablets.The clinical effect in the two groups after the treatment were compared.Enzyme linked immunosorbent assay was applied to detect IL-12, TGF-β and IFN-γ expressions in serum of two groups before and after the treatment, while flow cytometry was used to detect cellular immunity markers CD4+, CD8+, CD4+/CD8+ and other T lymphocyte subsets changes.[Results]The total effective rate was 84.37% (27/32) in the observation group, which was significantly higher than that in the control group (65.63%, 21/32);the difference was statistically significant (X2=7.682,P<0.05).After treatment, the expressions of IL-12 and IFN-γ in the serum of the observation group were significantly lower than those of the control group, while the expression of TGF-β was significantly higher than that of the control group (P<0.05).The immunity markers CD4+ and CD8+ in the observation group after the treatment were significantly lower than those in the control group, while CD4+/CD8+ was significantly higher than the control group (P<0.05).During the half-year follow-up, the recurrence rate was 9.38% (3/32) in the observation group, which was significantly lower than that in the control group (21.88%, 7/32);the difference was statistically significant (X2=6.552,P<0.05).The incidence of adverse reactions in the observation group was 25.00% (8/32), which was significantly higher than that in the control group (9.38%, 3/32) (X2=7.421,P<0.05).[Conclusion]The effect of total glucosides of paeony and tripterygium glycosides is significant in the treatment of oral lichen planus.They play a role by regulating cellular immunity, influencing expression and secretion of related cytokines.The efficacy of tripterygium glycosides is better than total glucosides of paeony.