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目的研究肝细胞生长因子受体c-met在小儿疝和鞘状突的分布,增加对小儿腹股沟疝发病机制的认识。方法2003年1月至12月,手术切除的腹股沟疝疝囊,鞘膜积液鞘膜囊和隐睾的鞘状突各20例以及10例腹膜,进行c-met免疫组化分析。结果腹股沟疝,鞘膜囊,隐睾和腹膜的间皮细胞c-met的阳性表达率分别是65%(13/20),55%(11/20),45%(9/20)和20%(2/10)。各组之间差异无显著性意义(χ2=7.7,P>0.05)。各组间质细胞c-met的阳性表达率分别是85%(17/20),75%(15/20),90%(18/20)和0。腹膜间质细胞c-met的阳性表达小于其他各组(χ2=30.1,P<0.01)。平均间质细胞的分布多于间皮细胞的分布(χ2=6.65,P<0.01)。结论肝细胞生长因子受体c-met在小儿疝囊、鞘膜、隐睾和腹膜的分布没有明显差别,说明肝细胞生长因子诱导小儿疝和鞘状突的闭合作用为非特异性,以及疝囊和鞘状突的闭合调控过程和肝细胞生长因子参与调控过程的复杂性。
Objective To investigate the distribution of hepatocyte growth factor receptor c-met in children with hernia and herniated hernias, and to increase the understanding of the pathogenesis of children with inguinal hernia. Methods From January 2003 to December 2003, c-met immunohistochemistry was performed in 20 cases of inguinal hernia sac, hydrocele of the hydrocele and cryptorchidism, and 10 cases of peritoneum. Results The positive rates of c-met in inguinal hernia, sheath, cryptorchid and peritoneal mesothelial cells were 65% (13/20), 55% (11/20), 45% (9/20) and 20 % (2/10). No significant difference between the groups (χ2 = 7.7, P> 0.05). The positive expression rates of c-met in each group were 85% (17/20), 75% (15/20), 90% (18/20) and 0 respectively. The positive expression of c-met in peritoneal interstitial cells was less than that in other groups (χ2 = 30.1, P <0.01). The average distribution of interstitial cells than mesothelial cells (χ2 = 6.65, P <0.01). Conclusion There is no significant difference in the distribution of c-met of hepatocyte growth factor receptor in infantile hernia sac, sheath, cryptorchidism and peritoneum, which indicates that hepatocyte growth factor induces the non-specific occlusion of pediatric hernia and herniated hernia, And the closure of the sheath process and the regulation of hepatocyte growth factor involved in the complexity of the regulatory process.