论文部分内容阅读
目的观察乙型肝炎(简称:乙肝)相关性肝移植术后接种乙肝疫苗预防乙肝复发的临床指标,探讨影响疫苗应答的相关因素。方法观察了9例应用乙型肝炎基因重组疫苗主动免疫的乙肝相关肝移植术后患者,分别在术后0、1、2、6个月接种,每次60μg,检测血清抗-HBs的滴度。结果 9例中,2例出现完全应答,停用乙型肝炎免疫球蛋白(hepatitis B immunoglobulin,HBIG);3例部分应答,HBIG减量,4例无应答。结论乙肝疫苗是预防乙肝相关性肝移植后乙肝复发的策略之一。接种时抗体滴度可能会增加疫苗的应答率。
Objective To observe the clinical indexes of hepatitis B (HBV) -related liver transplantation after hepatitis B vaccination in preventing recurrence of hepatitis B and to explore the relevant factors that influence the response of the vaccine. Methods Nine patients with HBV-related liver transplantation who were active immunized with hepatitis B gene recombinant vaccine were enrolled. The patients were vaccinated at 0, 1, 2, and 6 months after operation with 60 μg each for the detection of the serum anti-HBs titer . Results In 9 of the 9 patients, complete response was observed in 2 patients, and hepatitis B immunoglobulin (HBIG) was discontinued. Three patients responded partially to HBIG and four patients did not respond. Conclusion Hepatitis B vaccine is one of the strategies to prevent the recurrence of hepatitis B after liver transplantation. Antibody titers at vaccination may increase the vaccine’s response rate.