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RNA干扰(RNA interference)即转录后基因沉默,是由外源或内源性的双链RNA(double standed RNA)导入细胞而引起同源的mRNA降解,进而抑制其相应的基因表达。作为一项新技术,目前广泛地应用于生物体基因功能研究和多种肿瘤的研究。现针对大肠癌有关基因诊疗进行了积极的探索,并取得了突破性的进展。
RNA interference is a post-transcriptional gene silencing. It is introduced into cells by exogenous or endogenous double standed RNA to cause homologous mRNA degradation, thereby inhibiting its corresponding gene expression. As a new technology, it is widely used in the study of gene function of organisms and many kinds of tumors. Now for the diagnosis and treatment of colorectal cancer related to the positive exploration, and made a breakthrough.