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目的:为了控制难治肺结核病,研究在基层医院,应用纤维支气管镜给药治疗难治性肺结核的临床效果,分析其安全性。方法:选择我院2011年12月~2013年12月收治的难治性肺结核患者50例,随机分为对照组和观察组,各为25例。对照组采用常规化疗,观察组在对照组用药基础上联合纤维支气管镜给药治疗。疗程结束后总结痰菌阴转率、空洞缩小闭合率,病变范围吸收好转情况,评价治疗过程的安全性。结果:观察组痰菌阴转率为84%,空洞缩小闭合率达到了92%,对照组则分别是44%、44%,组间差异具有统计学意义(P<0.05)。结论:难治性肺结核患者,在常规给药的基础上联合纤维支气管镜给药治疗,明显提高痰菌阴转率和空洞缩小闭合率,效果明显高于常规疗法,值得推广。
OBJECTIVE: In order to control refractory pulmonary tuberculosis, the clinical efficacy of fibrobronchoscopy in the treatment of refractory pulmonary tuberculosis in primary hospitals was studied and its safety was analyzed. Methods: Fifty patients with refractory pulmonary tuberculosis admitted from December 2011 to December 2013 in our hospital were randomly divided into control group and observation group, with 25 cases each. Control group with conventional chemotherapy, the observation group in the control group based on the combination of bronchoscopy treatment. Conclusions after the end of treatment sputum negative conversion rate, cavity shrinkage closure rate, the absorption of the lesion improved the situation, evaluation of the safety of the treatment process. Results: In the observation group, the sputum negative conversion rate was 84%, the cavity closure rate was 92%, and the control group was 44% and 44% respectively. The difference between the two groups was statistically significant (P <0.05). Conclusion: In patients with refractory pulmonary tuberculosis, combined with conventional bronchoscopy and bronchofibroscopy, the sputum negative conversion rate and cavity closure rate are significantly improved, which is significantly higher than conventional therapy and worthy of promotion.