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目的:探讨转化生长因子β1(TGF-β1)、结缔组织生长因子(CTGF)在职业接尘者血清中表达水平的变化。方法:采集69例职业接尘者和43例健康对照者的外周静脉血,应用ELISA法检测血清TGF-β1和CTGF的表达水平。结果:职业接尘者和健康对照者血清TGF-β1含量分别为(55.83±9.02)、(19.33±4.57)μg/L,差异有统计学意义(t=16.87,P<0.05);血清CTGF含量分别为(297.60±29.63)、(127.33±15.38)ng/L,差异有统计学意义(t=2.60,P<0.05);血清TGF-β1和CTGF水平成正相关(r=0.186,P<0.05)。结论:血清TGF-β1、CTGF表达水平与接尘可能有关。
Objective: To investigate the changes of serum TGF-β1 and CTGF levels in occupational dust-exposed patients. Methods: Peripheral venous blood was collected from 69 cases of occupational exposure and 43 cases of healthy controls. Serum levels of TGF-β1 and CTGF were detected by ELISA. Results: The levels of TGF-β1 in serum of the workers exposed to the dust and the controls were (55.83 ± 9.02) and (19.33 ± 4.57) μg / L respectively, with significant difference (t = 16.87, P <0.05) (297.60 ± 29.63) and (127.33 ± 15.38) ng / L respectively, the difference was statistically significant (t = 2.60, P <0.05) ). Conclusion: The expression of serum TGF-β1 and CTGF may be related to the dust exposure.