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目的:探讨P-糖蛋白在大肠癌组织中的表达及临床诊断价值。方法:采用免疫组化SABC法检测P-gp蛋白和CEA在29例大肠癌和30例溃疡性结肠炎标本中的表达情况。结果:在大肠癌组织中P-gp表达的敏感性为65.5%,明显低于CEA的敏感性(96.8%),但P-gp的特异性为86.3%,明显高于CEA的特异性(57.6%)。在溃疡性结肠炎中P-gp表达的阳性率较低,而CEA表达的阳性率高达70%。结论:P-gp蛋白可在结肠组织中异位表达,对大肠癌的诊断特异性强、敏感性高,并可用于预测溃疡性结肠炎病变是否有癌变倾向。
Objective: To investigate the expression of P-glycoprotein in colorectal carcinoma and its clinical value. Methods: Immunohistochemical SABC method was used to detect the expression of P-gp protein and CEA in 29 cases of colorectal cancer and 30 cases of ulcerative colitis. Results: The sensitivity of P-gp expression in colorectal cancer was 65.5%, which was significantly lower than that of CEA (96.8%), but the specificity of P-gp was 86.3%, which was significantly higher than that of CEA %). The positive rate of P-gp expression in ulcerative colitis is low, while the positive rate of CEA expression is up to 70%. CONCLUSION: P-gp protein can be expressed ectopically in colonic tissue. It has high sensitivity and specificity for the diagnosis of colorectal cancer. It can be used to predict the tendency of malignant transformation of ulcerative colitis.