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目的探讨营养支持对慢性阻塞性肺病(COPD)急性加重期患者合并营养不良的疗效及其对肺功能的影响。方法COPD急性加重期合并营养不良患者40例,随机分为胃肠外营养(PN)组及对照组,在常规治疗基础上,给予为期2周的PN支持。结果(1)人体测量及生化检查:PN组实际体重占理想体重(IBW)的百分比、肱三头肌皮褶厚度(TSF)、上臂肌围(MAMC)及血清白蛋白明显增加(P<0.05),对照组无显著性变化(P>0.05)。(2)肺功能和血气检查:PN组的用力肺活量(FVC)、1秒用力呼气容积(FEV1)/FVC及血氧分压(PaO2)有明显改善(P<0.05),对照组无显著性变化(P>0.05)。结论PN支持可以改善COPD急性加重期患者肺功能,提高临床疗效。
Objective To investigate the effect of nutritional support on malnutrition in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) and its effect on pulmonary function. Methods Forty patients with acute exacerbation of COPD and malnutrition were randomly divided into parenteral nutrition (PN) group and control group. On the basis of routine treatment, PN support of 2 weeks was given. Results (1) Anthropometric and biochemical tests: The percentage of ideal body weight (IBW), triceps skin fold (TSF), MAMC and serum albumin in PN group were significantly increased (P <0.05 ), No significant change in the control group (P> 0.05). (2) Pulmonary function test and blood gas examination: FVC, FEV1 / FVC and PaO2 in PN group were significantly improved (P <0.05), but there was no significant difference in control group Sexual changes (P> 0.05). Conclusion PN support can improve lung function in patients with acute exacerbation of COPD and improve clinical efficacy.