偶然的摄入雌激素可诱发女童的青春发育,此时有乳腺胀大,乳晕深着色,有的甚至可出现月经。在鉴别诊断中必须排除中枢性性早熟及引起同性假性性早熟的其他原因如卵巢囊肿等。雌激素的摄入可通过饮食、服用含雌激素的药物或经皮吸收雌激素造成。本文报告1例女童因患严重的神经性皮炎,使用含雌激素润肤膏治疗湿疹近1年后发生假性性早熟的病例。 Occasional ingestion of estrogen can induce the girl’s youthful development, this time with breast enlargement, areola dark stained, and some may even have menstruation. In the differential diagnosis must rule out central precocious puberty and cause other causes of pseudo-precocious puberty such as ovarian cysts. Estrogen intake can be diet, taking estrogen-containing drugs or percutaneous absorption of estrogen. This article reports 1 case of girls suffering from severe neurodermatitis, the use of estrogen-containing body creams in the treatment of eczema almost a year after the occurrence of pseudo-precocious puberty cases.